Loss of mTOR repressors Tsc1 or Pten has divergent effects on excitatory and inhibitory synaptic transmission in single hippocampal neuron cultures.

The Pten and Tsc1 genes both encode proteins that repress mechanistic target of rapamycin (mTOR) signaling.Disruption of either gene in the brain results in epilepsy and autism-like symptoms in humans and mouse models, therefore it is important to understand the molecular and physiological events that lead from gene disruption to disease phenotypes

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Random sub-diffusion and capture of genes by the nuclear pore reduces dynamics and coordinates inter-chromosomal movement

Hundreds of genes interact with the yeast nuclear pore complex (NPC), localizing at the nuclear periphery and clustering with co-regulated genes.Dynamic tracking of peripheral genes shows that they Tubing:Pipe Clamps, Hangers cycle on and off the NPC and that interaction with the NPC slows their sub-diffusive movement.Furthermore, NPC-dependent int

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